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. 2011 Aug 31;31(35):12695–12704. doi: 10.1523/JNEUROSCI.4580-10.2011

Figure 4.

Figure 4.

Point mutations in mec-10 and mec-4 alter the reversal potential of the MRC, whereas a deletion in mec-10 does not affect the reversal potential. Current–voltage relations for MRCs recorded from PLM cells at the onset of a saturating mechanical stimulus in mutant (gray) and wild-type (black) animals (mean ± SEM). MRCs were recorded at −114 to +66 mV in 20 mV increments. Current was normalized (Inorm) to the current recorded at a holding potential of −114 mV, and membrane potential (Vm) was adjusted for voltage attenuation as described in Materials and Methods. A, mec-10(ok1104) (n = 4) compared with wild-type (n = 7). B, mec-10(u390) (n = 3), mec-10(u332) (n = 4), and mec-10(e1715) (n = 4) compared with wild-type (n = 7). C, mec-10(e1515) (n = 3) and mec-4(u339) (n = 3) compared with wild type (n = 7).