Table 1.
Kinetics of “on” and “off” MRCs
| Genotype | On |
Off |
||||
|---|---|---|---|---|---|---|
| Latency (ms) | t1 (ms) | τ2 (ms) | Latency (ms) | τ1 (ms) | τ2 (ms) | |
| Wild type | 0.7 ± 0.1 | 2.6 ± 0.2 | 51 ± 3 | 1.9 ± 0.1 | 2.0 ± 0.2 | 49 ± 6 |
| (n = 23) | (n = 12) | (n = 12) | (n = 23) | (n = 12) | (n = 12) | |
| ok1104 | 0.7 ± 0.1 | 4.2 ± 0.3* | 67 ± 3* | 1.8 ± 0.1 | 1.6 ± 0.1 | 41 ± 3 |
| (n = 10) | (n = 10) | (n = 10) | (n = 10) | (n = 10) | (n = 10) | |
| e1515 | 1.0 ± 0.2 | 2.7 ± 0.5 | 48 ± 6 | 3.0 ± 0.3* | 2.3 ± 0.2 | 47 ± 3 |
| (n = 5) | (n = 5) | (n = 5) | (n = 5) | (n = 5) | (n = 5) | |
| u332 | 0.8 ± 0.1 | 2.9 ± 0.2 | 49 ± 4 | 2.7 ± 0.2* | 1.5 ± 0.1 | 20 ± 2* |
| (n = 8) | (n = 7) | (n = 7) | (n = 8) | (n = 7) | (n = 7) | |
Average latency, activation (τ1), and adaptation (τ2) time constants were calculated from MRC responses to stimuli of at least 40 nN/μm2 [mean ± SEM, n is number of recordings;
*p < 0.05, one-way ANOVA and subsequent pairwise comparisons (Tukey's test)].