Table 2.

Effects of modifications of the pyridazine on EAAT2 protein levels

Compound	X	Y	Z	R	Fold for increase EAAT2a
					4 h	24 h
7–4	S	N	N	2-Me-Bn	1.7 ± 0.1	3.5 ± 0.3
22	S	C	N	2-Me-Bn	1.3 ± 0.6	nab
8–1	O	N	N	2-Me-Bn	2.0 ± 0.9	2.5 ± 0.5
15	O	N	C	2-Me-Bn	1.5 ± 0.3	na
7–12	S	N	N	Bn	1.3 ± 0.2	3.0 ± 0.4
19	S	C	C	Bn	1.2 ± 0.5	1.1 ± 0.4

^aCompound concentration of 10 μM;

^bna = not activ