Table 3.

Effects of modifications of the sulfur linker on EAAT2 protein levels

Compound	X	R	Fold increase for EAAT2a
			4 h	24 h
1	S	2-Cl-6-F-Bn	nab	2.0 ± 0.8
8–2	O	2-Cl-6-F-Bn	1.1 ± 0.3	2.9 ± 0.4
7–4	S	2-Me-Bn	1.7 ± 0.1	3.5 ± 0.3
8–1	O	2-Me-Bn	2.0 ± 0.9	2.5 ± 0.5
7–13	S	2,6-di-Me-Bn	na	6.5 ± 1.0
8–3	O	2,6-di-Me-Bn	2.1 ± 1.2	3.2 ± 1.4
7–14	S	1-(2-Cl-6-F-phenyl)ethyl	1.7 ± 0.9	5.5 ± 1.0
8–4	O	1-(2-Cl-6-F-phenyl)ethyl	1.6 ± 0.2	3.0 ± 0.7
7–15	S	2-(2-Cl-6-F-phenylethyl)	1.9 ± 0.7	6.7 ± 1.5
8–5	O	2-(2-Cl-6-F-phenylethyl)	2.2 ± 0.4	3.1 ± 1.2
7–16	S	2,4-di-F-Bn	2.4 ± 1.5	3.8 ± 0.8
8–6	O	2,4-di-F-Bn	na	2.3 ± 0.6
7–17	S	2,4-di-Me-Bn	1.9 ± 0.8	6.4 ± 1.0
8–7	O	2,4-di-Me-Bn	na	2.0 ± 0.9
6–1	S	H	na	2.0 ± 0.8
5–1	O	H	1.5 ± 0.5	1.6 ± 1.0
14	NH	2-Me-Bn	1.7 ± 1.1	2.6 ± 0.5
9–1	SO2	2-Cl-6-F-Bn	1.4 ± 0.3	2.8 ± 0.4
9–2	SO2	2-Me-Bn	2.3 ± 0.4	1.1 ± 0.2
9–3	SO2	2-Cl-Bn	1.6 ± 0.3	na
17–1	CONH	n-Pr	na	1.2 ± 0.2
17–2	CONH	2-Me-Bn	na	1.4 ± 0.2

^aCompound concentration of 10 μM;

^bna = not active