Table 4.

Effects of the benzyl group on EAAT2 protein levels

Compound	R	Fold increase for EAAT2a
		4 h	24 h
1	2-Cl-6-F-Bn	nab	2.0 ± 0.8
7–7	2-Cl-Bn	2.1 ± 1.4	4.0 ± 0.3
7–18	3-Cl-Bn	2.1 ± 0.3	4.1 ± 0.5
7–19	2,3-di-Cl-Bn	na	2.4 ± 0.4
7–20	2,5-di-Cl-Bn	1.4 ± 0.1	2.5 ± 0.4
7–21	2,4-di-Cl-Bn	1.8 ± 0.5	na
7–22	2,6-di-Cl-Bn	1.5 ± 0.8	3.9 ± 0.4
7–23	2-F-Bn	2.2 ± 0.1	3.1 ± 0.2
7–24	4-F-Bn	2.5 ± 0.6	2.6 ± 0.3
7–16	2,4-di-F-Bn	2.4 ± 1.5	3.8 ± 0.8
7–25	2,6-di-F-Bn	2.1 ± 1.4	2.2 ± 0.7
7–26	2,4,6-tri-F-Bn	1.6 ± 1.0	2.4 ± 0.6
7–4	2-Me-Bn	1.7 ± 0.1	3.5 ± 0.3
7–27	3-Me-Bn	2.0 ± 0.2	2.8 ± 0.5
7–28	4-Me-Bn	2.1 ± 1.1	2.6 ± 0.4
7–29	2,4-di-Me-Ph	1.2 ± 0.3	2.2 ± 0.3
7–17	2,4-di-Me-Bn	1.9 ± 0.8	6.4 ± 1.0
7–13	2,6-di-Me-Bn	na	6.5 ± 1.0
7–30	2,4,6-tri-Me-Bn	1.7 ± 0.3	4.7 ± 0.5
7–15	2-(2-Cl-6-F-phenylethyl)	1.9 ± 0.7	6.7 ± 1.5
7–31	2-(2-Cl-phenylethyl)	1.7 ± 0.2	4.8 ± 0.6
7–32	2-(2-Me-phenylethyl)	1.2 ± 0.3	2.8 ± 0.4
7–33	1-(1,2,3,4-tetrahydronaphthalenyl)	na	5.3 ± 1.1
7–14	1-(2-Cl-6-F-phenyl)ethyl	1.7 ± 0.9	5.5 ± 1.0
7–34	2-Cl-4-F-Ph	1.3 ± 0.1	2.5 ± 0.7
7–35	2-Cl-4-F-Bn	1.6 ± 0.6	1.7 ± 0.4
7–12	Bn	1.3 ± 0.2	3.0 ± 0.5
7–36	Et	1.6 ± 0.7	1.9 ± 0.9
6–1	H	na	2.0 ± 0.8

^aCompound concentration of 10 μM;

^bna = not active