TABLE 1. Demographic and Pretreatment Clinical Characteristics of the Randomized Sample.
Placebo (N = 37) | Naltrexone (N = 37) | Test Statistic | p | |
---|---|---|---|---|
Age, years | 62.5 (5.6) | 64.2 (6.9) | t = −1.17 | 0.248 |
Male, % | 81.1 | 78.4 | χ2=0.08 | 0.772 |
Caucasian, % | 64.9 | 67.6 | χ2=0.06 | 0.806 |
Recruitment site, % VA | 29.7 | 32.4 | χ2=0.06 | 0.802 |
Ham-D | 23.4 (5.0) | 20.1 (5.7) | t=2.60 | 0.011 |
Days heavy drinking, % | 75.8 (29.1) | 59.2 (35.6) | t=2.190 | 0.032 |
Days drinking, % | 82.4 (24.5) | 75.5 (29.3) | t=1.11 | 0.270 |
Drinks/drinking day | 10.2 (6.8) | 6.5 (3.9) | t=2.84 | 0.006 |
ASI Alcohol Score | 0.67 (0.18) | 0.64 (0.17) | t=0.79 | 0.433 |
PCS | 43.8 (8.5) | 46.1 (10.3) | t = −0.99 | 0.325 |
MCS | 33.2 (9.6) | 38.1 (11.5) | t = −1.91 | 0.061 |
With primary depression, % | 68.6 | 65.7 | χ2=0.07 | 0.799 |
Note: Those subjects randomized to placebo had significantly greater depressive symptoms and pretreatment heavy-drinking days. Values are mean (standard deviation) for continuous measures and percentages for categorical measures.
Ham-D: Hamilton Rating Scale for Depression; ASI: Addiction Severity Index; PCS: Physical Component Score from the Medical Outcomes Scale (SF-36); MCS: Mental Component Score from the Medical Outcomes Scale (SF-36).