. Author manuscript; available in PMC: 2012 Sep 8.

Published in final edited form as: J Med Chem. 2011 Aug 5;54(17):6014–6027. doi: 10.1021/jm200454y

Table 4.

Inhibition of Cell Proliferation by 8 and 4

entry	cell line^a	cell type	8 IC₅₀ (nM)	4 IC₅₀ (nM)
1	activated HAAE-1	endothelial cell	0.1 (120)^b	2.2 (1.7)^b
2	quiescent HAAE-1	endothelial cell	12	1.3
3	U87-MG	brain glioblastoma	0.41	2.6
4	DU145	prostate carcinoma	0.36	4
5	Calu-6	lung anaplastic carcinoma	0.16	0.94
6	MDA-MB-231	breast adenocarcinoma	0.63	3.2
7	A431	epidermoid carcinoma	18.6	188
8	A375	malignant skin melanoma	1.5	2.1
9	SKOV-3	ovary adenocarcinoma	0.59	5.5
10	LoVo	colorectal adenocarcinoma	0.24	2.9
11	AU565	breast adenocarcinoma	5.8	4.4
12	BT549	breast carcinoma	0.34	3.5

HAAE-1 cells were seeded at 500 cells/well in medium containing 0.03 mg/mL endothelial cell growth supplement (activated) or in basal medium containing 0.5% fetal calf serum and antibiotics (quiescent). Cancer cell lines were seeded at an average of 500–2000 cells/well and cultured as recommended by the ATCC.

Selectivity ratio (IC₅₀ quiescent)/(IC₅₀ activated) in parentheses.