Table 5.
Effect of MDR-1 Inhibition on the Potency of Antitubulin Drugs toward Renal Carcinoma Cell Line 786-0
| conditions | drug IC50 (nM) against 786-0 cells
|
|||
|---|---|---|---|---|
| paclitaxel | vincristine | vinblastine | 8 | |
| drug alone | 31 | 37 | 4.5 | 0.58 |
| drug + verapamil | 4.0 | 1.2 | 0.31 | 0.39 |