Table 7.
Pharmacokinetic Properties of 4 and 8
| parameter | compda |
|
|---|---|---|
| 4 | 8 | |
| dose (μmol/kg) | 6 | 6 |
| t1/2 (h) | 0.7 | 3.5 |
| VSS (L/kg) | 7.3 | 7.1 |
| AUC0–∞ | 36 | 48 |
| PPB (% bound) | 98.9 | 81.4 |
a
Plasma concentration–time profiles are provided in the Supporting Information.
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