Table 1.

Body temperature, blood gas values, and MAP for treatment groups

Group	Body temperature	PaO2	PaCO2	pH	MAP
Baseline
aCSF + 0.1% BSA	37.6 ± 0.1	266.8 ± 10.0	45.0 ± 0.6	7.340 ± 0.009	121.2 ± 5.0
VEGF	37.6 ± 0.2	272.2 ± 8.0	45.4 ± 0.6	7.344 ± 0.006	125.0 ± 5.3
U0126 + VEGF	37.5 ± 0.2	270.2 ± 8.5	46.3 ± 0.7	7.338 ± 0.008	124.7 ± 3.4
LY294002 + VEGF	37.1 ± 0.2	272.7 ± 11.2	44.9 ± 0.9	7.355 ± 0.006	107.7 ± 7.0
15 min
aCSF + 0.1% BSA	37.6 ± 0.1	260.8 ± 10.9	44.6 ± 0.8	7.342 ± 0.012	122.9 ± 3.9
VEGF	37.6 ± 0.2	270.4 ± 8.7	45.0 ± 0.5	7.343 ± 0.007	122.1 ± 5.0
U0126 + VEGF	37.5 ± 0.2	265.9 ± 7.9	46.6 ± 0.4	7.337 ± 0.008	126.4 ± 4.2
LY294002 + VEGF	37.2 ± 0.1	259.6 ± 11.9	44.3 ± 0.8	7.346 ± 0.010	96.5 ± 3.7
30 min
aCSF + 0.1% BSA	37.6 ± 0.1	259.2 ± 10.9	44.4 ± 0.8	7.345 ± 0.012	122.8 ± 4.7
VEGF	37.5 ± 0.1	265.2 ± 9.0	46.0 ± 0.6*	7.335 ± 0.007	118.3 ± 5.5**
U0126 + VEGF	37.4 ± 0.1	267.5 ± 7.5	46.7 ± 0.7	7.337 ± 0.009	124.2 ± 4.7
LY294002 + VEGF	37.2 ± 0.1	258.7 ± 11.9	46.9 ± 0.7	7.353 ± 0.010	105.9 ± 8.5
60 min
aCSF + 0.1% BSA	37.5 ± 0.2	264.1 ± 10.1	44.8 ± 0.8	7.348 ± 0.012	119.7 ± 3.9
VEGF	37.6 ± 0.2	264.1 ± 8.6	46.0 ± 0.6	7.332 ± 0.011	113.1 ± 5.8**
U0126 + VEGF	37.5 ± 0.1	265.8 ± 7.3	45.8 ± 0.5	7.341 ± 0.011	124.9 ± 6.1
LY294002 + VEGF	37.1 ± 0.2	273.1 ± 5.1	45.2 ± 0.6	7.356 ± 0.009	105.2 ± 7.3
90 min
aCSF + 0.1% BSA	37.5 ± 0.2	268.6 ± 9.7	44.9 ± 0.7	7.350 ± 0.013	117.0 ± 4.7
VEGF	37.5 ± 0.2	266.7 ± 9.6	46.0 ± 0.7	7.332 ± 0.012	102.6 ± 9.5**
U0126 + VEGF	37.4 ± 0.2	265.2 ± 7.8	45.9 ± 0.6	7.340 ± 0.012	121.6 ± 9.5
LY294002 + VEGF	37.1 ± 0.1	267.8 ± 9.8	45.2 ± 0.4	7.353 ± 0.011	100.4 ± 8.3

All values expressed as mean ± SEM.

* indicates significantly different from 15 min time point in VEGF-treated group;

** indicates significantly different from baseline values of VEGF-treated group.