a. The temperature trajectories for three representative replicas with the effective temperature of the protein initially at low (T = 310K), intermediate (T = 419K), and high (T = 684K) temperatures for the β-hairpin system. b. The protein heavy atom RMSD versus time at each of the above temperatures when replicas visit those temperatures. (Black, T = 310K; Red, T = 419K; Green, T = 684K)