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. Author manuscript; available in PMC: 2012 Aug 26.
Published in final edited form as: Chem Biol. 2011 Aug 26;18(8):1021–1031. doi: 10.1016/j.chembiol.2011.07.015

Figure 4.

Figure 4

(A) Proposed biosynthesis of TW94b, TW94c and TW94d by the fdm minimal PKS and the act KR in S. coelicolor CH999/pAD201/pBOOST*. The act KR is a ketoreductase from the actinorhodin biosynthetic pathway. (B) Proposed biosynthesis of AD210a by the bimodular fdm PKS in S. coelicolor CH999/pAD210/pBOOST*. The DH (dehydratase) and ER (enoyl reductase) involved in the initiation module are derived from the housekeeping fatty acid synthase in S. coelicolor. (C) Proposed biosynthesis of fredericamycin A in S. griseus.