Table 2.

(A)List of the variants with their corresponding mutations. Variant numbers are listed in the 1st column, and the mutations harbored by them are listed the corresponding row. A “1” in a given cell (highlighted in purple for enhanced identification) indicates that the mutation was incorporated into that variant. See also Figure S8. (B) In vivo product profile of fdm CLF variants. Set 1 includes variants whose design was based on high “alternate conservation” scores, whereas Set 2 includes variants designed based on “entropy” scores. For details, see text.