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. Author manuscript; available in PMC: 2012 Sep 30.
Published in final edited form as: Respir Physiol Neurobiol. 2011 Jun 25;178(3):482–489. doi: 10.1016/j.resp.2011.06.017

Figure 3.

Figure 3

The effects of systemic LPS on pLTF, with and without a known microglial inhibitor (minocycline). Both LPS and minocycline diminish AIH-induced pLTF. A) Compressed phrenic neurograms from in vivo anesthetized, vagotomized, paralyzed, ventilated rats demonstrating typical AIH-induced pLTF (upper trace), and reduced pLTF 3 hrs post-LPS (3 mg/kg, i.p.; lower trace). B) Group data demonstrating significant reduction in pLTF with LPS, LPS and minocycline (30 mg/kg, i.v.) and minocycline alone. (** p<0.01, *** p<0.001 indicates significant difference from vehicle response). Statistics: one-way ANOVA with Fisher's LSD post hoc test.