TABLE 2.

DISTRIBUTION OF PERCENT METHYLATION OF CPG LOCI IN NITRIC OXIDE SYNTHASE AND ARGINASE GENES

Gene Loci	Location	N*	Mean	SD	Interquartile Range
NOS1
Average†	Nonisland	908	73.57	4.86	6.36
Position 1	Nonisland	905	68.65	6.48	8.84
Position 2	Nonisland	894	89.66	4.14	5.29
Position 3	Nonisland	884	62.33	6.90	8.22
NOS2A
Promoter average†	Nonisland	896	94.32	2.59	2.99
Position 1	Nonisland	896	91.65	2.48	2.82
Position 2	Nonisland	892	97.03	3.26	4.55
Position 3	Nonisland	916	51.31	4.29	5.79
CpG island average†	Island	940	1.49	2.46	0.89
Position 4	Island	940	2.08	3.05	1.72
Position 5	Island	939	1.76	3.16	2.03
Position 6	Island	939	1.01	2.39	1.11
Position 7	Island	940	1.12	2.18	1.20
NOS3
Average†	Nonisland	914	89.89	5.37	5.96
Position 1	Nonisland	914	89.16	7.00	7.32
Position 2	Nonisland	914	90.61	5.97	6.27
ARG1
Position 1	Nonisland	921	64.37	4.60	6.05
ARG2
Average†	Island	876	1.84	2.55	1.34
Position 1	Island	876	1.29	2.74	1.32
Position 2	Island	875	1.57	3.01	1.58
Position 3	Island	875	2.64	3.12	2.38

^*Sample size varies as a result of quality control screening for pyrosequencing reactions.

^†Average methylation of multiple positions within the gene was used.