TABLE 3.
THE ASSOCIATION BETWEEN PERCENT METHYLATION OF ARGINASE GENES AND PERCENT CHANGE IN FRACTIONAL CONCENTRATION OF NITRIC OXIDE FROM LINEAR REGRESSION MODELS, CHILDREN'S HEALTH STUDY 2004–2007
| Combined* |
Children with Asthma† |
Children with No Asthma |
|||||||||
| Gene Loci | % Difference | 95% Confidence Interval | N | % Difference | 95% Confidence Interval | N | % Difference | 95% Confidence Interval | N | Pint* | |
| ARG1 | Position 1 | −0.1 | (−1.1 to 0.9) | 921 | −4.4 | (−8.2 to −0.3) | 130 | 0.3 | (−0.7 to 1.2) | 791 | 0.02 |
| ARG2 | Average‡ | −2.3 | (−4 to −0.6) | 876 | −8.7 | (−14.6 to −2.4) | 120 | −1.6 | (−3.3 to 0.1) | 756 | 0.01 |
| Position 1 | −1.6 | (−3.1 to −0.03) | 876 | −7.6 | (−13.3 to −1.6) | 120 | −1.1 | (−2.6 to 0.5) | 756 | 0.02 | |
| Position 2 | −1.1 | (−2.6 to 0.3) | 875 | −5.3 | (−11.5 to 1.2) | 120 | −0.8 | (−2.2 to 0.6) | 755 | 0.09 | |
| Position 3 | −2.6 | (−4 to −1.1) | 875 | −7.2 | (−11.9 to −2.3) | 120 | −1.8 | (−3.3 to −0.3) | 755 | 0.02 | |
*
P value testing the interaction between arginase DNA methylation and asthma status in a model adjusted for age, sex, race,plate, town, month of DNA collection, asthma medicine used, education, and asthma.
†
Analyses are adjusted for age, sex, race, plate, town, month of DNA collection, asthma medicine used, and education.
‡
Average methylation of three positions within ARG2 gene was used.