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. 2011 Apr 14;184(1):82–91. doi: 10.1164/rccm.201012-1967OC

Figure 5.

Figure 5.

Monocyte/macrophage (MOMA)-2 staining in aortic valve from ME-exposed ApoE−/− mice treated with lectin-like oxidized low-density lipoprotein receptor (LOX-1) neutralizing antibody for 7 days. (A) Mixed emissions-exposed (ME) + IgG (mouse IgG control); (B) filtered air (FA) control + IgG (mouse IgG control); (C) ME + anti-LOX antibody (Ab) (LOX-1); (D) FA + anti-LOX Ab (LOX-1); (E) analysis of % stained area for sections (n = 6–8 sections per animal, n = 5 animals per exposure/treatment group); MOMA-2–stained areas were divided by total lesion area. *P < 0.050 compared with FA control, †P ≤ 0.050 compared with ME-exposed. Red/brown staining indicates positive MOMA-2 area; arrows indicate increased MOMA-2 regions in tunica intima and atherosclerotic plaque regions. 2× pictures with 10× insets.