Figure 7.

Human and mouse plasma sLOX levels in response to ME and DE exposure. (A) ApoE^−/− mouse plasma soluble lectin-like oxidized low-density lipoprotein receptor (sLOX) levels in response to either filtered air (FA) or mixed exhaust (ME) exposure concurrent with anti-LOX antibody (Ab) (LOX-1, LOX-1/SR-E1 antibody) or IgG (IgG control) as measured by Western blot, and quantified by (B) densitometry from three separate experiments (n = 3 per group). Arrow indicates 30-kD band confirmed as sLOX. (C) Human plasma sLOX levels in response to filtered air (FA) versus diesel exhaust (DE, 100 μg/m³) exposure for 2 hours, as quantified by ELISA. Data presented as the difference from preexposure to each postexposure value (30 min post and 24 h post). (D) Linear regression of the relationship between the magnitude of relative sLOX response (at 30 min post) between FA and DE exposures and the serum triglyceride levels for each human subject. Details of the relationships between exposure and other plasma lipids are presented in Table 2. *P < 0.050 compared with control, ^†P ≤ 0.050 compared with ME-exposed, ***P < 0.001 compared with control.