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. 2011 Apr 14;184(1):124–131. doi: 10.1164/rccm.201012-2039OC

Figure 3.

Figure 3.

(A) Effect of U75302 and LY255283 on 5-lipoxygenase (5-LO) mRNA expression in THP-1 cells after exposure to intermittent hypoxia (IH) for 24 hours. (B) Effect of U75302 and LY255283 on leukotriene A4 hydrolase (LTA4H) mRNA expression in THP-1 cells after exposure to IH for 24 hours. (C) Diagram representing putative signalings of IH-induced leukotriene B4 (LTB4) production and its regulation. Data are expressed as a percentage of control RA (mean ± SE; n = 8; *P < 0.01 vs. RA; #P < 0.05 vs. IH). MAPK = mitogen-activated protein kinase; NF-κB = nuclear factor-kappa B.