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. 2011 Jul 12;105(3):382–392. doi: 10.1038/bjc.2011.244

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Copyright © 2011 Cancer Research UK

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.

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Pro-apoptotic activity of two MEK inhibitors, MSC19363669B (A) and selumetinib (B), on TKI-R CALU-3. TKI-R CALU-3 cells were treated for the indicated time with two MEK inhibitors, MSC19363669B and selumetinib, at the showed doses. Apoptosis was assessed by a modified TUNEL assay as described in Materials and Methods section.