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. 2011 Jul 5;105(3):407–412. doi: 10.1038/bjc.2011.246

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Copyright © 2011 Cancer Research UK

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Role of STAT3 in MET-TKI-induced apoptosis in gastric cancer cells. (A) OKAJIMA or 58As9 cells infected with a retrovirus encoding FLAG-tagged STAT3-CA or with the empty virus (mock) were incubated in medium containing 10% serum for 48 h in the absence or presence of PHA-665752 at 0.1 or 0.5 μM. Cell lysates were then subjected to immunoblot analysis with antibodies to total or phosphorylated forms of MET, FLAG, PARP, or caspase-3. The positions of full-length and cleaved (cl-) forms of PARP and caspase-3 are indicated. (B) Cells treated as in A were assayed for DNA fragmentation as described in Materials and Methods. Data are expressed as fold change relative to the corresponding value for mock infected cells not exposed to PHA-665752 and are means±s.d. from three independent experiments. ^*P<0.05 for the indicated comparisons.