Table 1.
Effect of ribavirin and MPA on CBV3 replication in Vero cells and human myocardial fibroblasts (HMF)
EC50 (μg/ml)a | Yield reductionb (%) | MTC (μg/ml)c | ||
Vero | HMF | |||
MPA | 55 | 80 | 89 | 200 |
Ribavirin | 117 | 250 | 87 | >500 |
aConcentration of compound that reduces viral induced cytopathic effect by 50% bReduction of virus yield in Vero cells in the presence of 100 μg/ml of either compound cAs determined in Vero cells. Minimal toxic concentration, or correlation required to other normal cell morphology