Table 1. Patient and tumour characteristics (n=102).
|
Patients treated with anthracyclines (n=44)
|
Patients treated with taxane–trastuzumab (n=58)
|
||||
|---|---|---|---|---|---|
| N | % | N | % | P | |
| Age (years) | |||||
| <50 | 24 | 54 | 32 | 55 | |
| ⩾50 | 20 | 46 | 26 | 45 | 0.89 |
| Tumour initial stage | |||||
| T2 | 18 | 41 | 36 | 62 | |
| T3–T4 | 26 | 59 | 22 | 38 | 0.06 |
| Axillary nodal status | |||||
| Positive | 38 | 86 | 35 | 60 | |
| Negative | 6 | 14 | 23 | 40 | 0.01 |
| Tumour grade | |||||
| I+II | 18 | 41 | 37 | 64 | |
| III | 26 | 59 | 21 | 36 | 0.04 |
| Oestrogen receptor | |||||
| Positive | 17 | 39 | 33 | 57 | |
| Negative | 27 | 61 | 25 | 43 | 0.10 |
| Pathological complete response | |||||
| Yes | 8 | 18 | 24 | 41 | |
| No | 36 | 82 | 34 | 59 | 0.02 |
| T-bet+ infiltrates before CT | |||||
| Yes | 9 | 21 | 13 | 22 | |
| No | 35 | 79 | 45 | 78 | 0.99 |
| T-bet+ infiltrates after CT | |||||
| Yes | 7 | 16 | 29 | 50 | |
| No | 37 | 84 | 29 | 50 | 0.0008 |
| T-bet+ induction | |||||
| Yes | 6 | 14 | 22 | 38 | |
| No | 38 | 86 | 36 | 62 | 0.01 |
| Relapse | |||||
| Yes | 26 | 59 | 14 | 24 | |
| No | 18 | 41 | 44 | 76 | 0.0007 |
| Death | |||||
| Yes | 23 | 52 | 2 | 4 | |
| No | 21 | 48 | 56 | 96 | <0.0001 |
Abbreviation: CT=chemotherapy.