Table 2. Informativity studies performed in each family.

Family	No. of meioses between a common ancestor and all affected individuals	Number of common ancestors	Number of disease allele transmissions to affected individuals	Expected maximum lod score	Probabilities to reach Zimax under H0, 0, 1 or more than once in whole-genome analysis
(Fi)	(Mi)	(ni)	(Ti=Mi-ni)	(Zimax=−Ti log10(0.5))	0	1	>1
F1	9	4	5	1.51	0.253	0.346	0.401
F2	12	2	10	3.01	0.958	0.041	0.001
F3	10	1	9	2.71	0.918	0.079	0.003

Only affected individuals have been taken into account.