Table 1. Clinical characteristics of MMR mutation carriers.
| Number of subjects (%) (n=748) | Number of incident CRC cases (n=329) | Log-rank test, P-value | |
|---|---|---|---|
| Gender | |||
| Male | 349 (46.7) | 177 | <0.0001 |
| Female | 399 (53.3) | 152 | |
| Index case | |||
| Yes | 290 (38.8) | 259 | |
| No | 458 (61.2) | 70 | |
| MMR gene mutated | |||
| MSH2 | 414 (55.4) | 178 | 0.0495 (vs MSH6) |
| MLH1 | 267 (35.7) | 115 | 0.0069 (vs MSH6) |
| MSH6 | 67 (8.9) | 36 | |
| Year of birth | |||
| <1940 | 57 (7.6) | 39 (11.8) | |
| 1940–1949 | 106 (14.2) | 73 (22.2) | |
| 1950–1959 | 188 (25.1) | 119 (36.2) | |
| 1960–1969 | 165 (22.1) | 66 (20.1) | |
| 1970–1979 | 129 (17.2) | 26 (7.9) | |
| ≥1980 | 103 (13.8) | 6 (1.8) | |
|
Age |
Mean, min/max |
||
| With CRC | 329 (44) | 43, 18/82 | |
| Without CRC | 419 (56) | 38, 18/78 | |