Table 3. Haplotype frequencies of PTGES variations in female patients with RA and female controls from the Swedish and the Dutch populations.

Haplotype		HF	HF, cases	HF, controls	OR (95% CI)	P	P*
The Swedish population
CCT	All	0.843	0.837	0.854	0.88 (0.76–1.02)	0.09	NS
	F	0.842	0.831	0.862	0.78 (0.66–0.93)	0.0066	0.0172
	M	0.844	0.851	0.828	1.19 (0.90–1.57)	0.22	NS
TTC	All	0.130	0.137	0.117	1.19 (1.01–1.40)	0.03	NS
	F	0.128	0.139	0.107	1.34 (1.11–1.63)	0.0030	0.0077
	M	0.136	0.131	0.146	0.88 (0.65–1.18)	0.39	NS
TCT	All	0.011	0.011	0.011	0.93 (0.56–1.57)	0.75	NS
	F	0.012	0.012	0.013	0.97 (0.55–1.71)	0.86	NS
	M	0.005	0.004	0.007	0.54 (0.16–1.8)	0.30	NS
The Dutch populations
CCT	All	0.835	0.836	0.834	1.01 (0.85–1.20)	0.83	NS
	F	0.844	0.841	0.855	0.89 (0.65–1.24)	0.50	NS
	M	0.827	0.826	0.827	0.99 (0.78–1.25)	0.97	NS
TTC	All	0.126	0.128	0.125	1.01 (0.84–1.23)	0.82	NS
	F	0.12	0.125	0.105	1.21 (0.84–1.75)	0.29	NS
	M	0.131	0.132	0.131	1.00 (0.77–1.30)	0.97	NS
TCT	All	0.02	0.018	0.025	0.16 (0.46–1.13)	0.13	NS
	F	0.02	0.019	0.021	0.90 (0.40–2.00)	0.80	NS
	M	0.02	0.015	0.025	0.61 (0.31–1.19)	0.14	NS

Abbreviations: NS, not significant; HF, haplotype frequency; F, females; M, males.

Haplotypes are based on PTGES SNPs rs10988484, rs11999368 and rs16931419 and are considered only with the frequency above 0.01. *P-value after 1 000 000 permutations.