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. Author manuscript; available in PMC: 2012 Aug 16.
Published in final edited form as: Biochemistry. 2011 Jul 18;50(32):6973–6982. doi: 10.1021/bi2004526

Table 3. Thrombin Amino Acid Residues that Interact with Sulfate Groups of Heparin and SOS in their Crystal Complexes.

K87 H91 R93 R101 R/K126 R165 R233 K235 K236 W237 K240 R244
Heparin – HT graphic file with name nihms-312522-ig0008.jpg ✓ ✓ ✓ ✓ ✓ ✓ graphic file with name nihms-312522-ig0009.jpg ✓ ✓ ✓ graphic file with name nihms-312522-ig0010.jpg
SOS – BT ✓ ✓ ✓ ✓ ✓ graphic file with name nihms-312522-ig0011.jpg ✓ ✓ ✓ ✓ ✓

✓ amino acid interacts with sulfate group in crystal complex

Inline graphic amino acid does not interact with sulfate group in crystal complex