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Multi-analyte detection of salivary biomarkers predicts periodontal disease status. Receiver operator curves (ROC) of combinatorial permutations of salivary biomarkers [matrix metalloproteinase-8 (MMP-8), C-telopeptide (ICTP), osteoprotegerin (OPG)] coupled with biofilm subgingival pathogens such as Treponema denticola measured by quantitative PCR. AUC = area under the curve; OR = odds ratio; numbers in brackets are 95% confidence intervals. From Ramseier et al. (2009).
