Table 3.
Variable Importance (VIP) for Bacteria Associated with Mode of Delivery from PLS-DA Multivariate Modeling
| Associated with Vaginal Delivery | Associated with Caesarian Section Delivery | ||
|---|---|---|---|
| Bacterial Group1 | VIP | Bacterial Group1 | VIP |
| Streptococcus sanguinis | 1.50 | Slackia exigua | 3.26 |
| Cardiobacterium hominis | 1.50 | Lactobacillus Cluster I3 | 1.85 |
| Streptococcus anginosus, Streptococcus gordonii | 1.44 | Veillonella sp. EF509966 (intestinal isolate) | 1.54 |
| Prevotella Cluster I2 | 1.43 | Veillonella atypica, Veillonella parvula | 1.51 |
| Prevotella loescheii, Prevotella sp. HOT 472 | 1.43 | Streptococcus parasanguinis I and II | 1.34 |
| Eubacterium [11] [G-7] yurii | 1.43 | Veillonella parvula | 1.23 |
| Catonella morbi, Catonella sp. HOT 164 | 1.43 | Gemella haemolysans | 1.32 |
| TM7 [G-1] sp. HOT 347, TM7 [G-2] sp. HOT 350 | 1.43 | Gemella morbillorum | 1.26 |
| Haemophilus parainfluenzae | 1.41 | Streptococcus australis | 1.20 |
| Leptotrichia buccalis, Leptotrichia goodfellowii, Sneathia sanguinegens | 1.31 | Bifidobacterium animalis ss. animalis, Bifidobacterium lactis | 1.13 |
| Bacteroidetes phylum | 1.28 | Streptococcus cristatus | 1.08 |
| Campylobacter gracilis | 1.27 | Kingella oralis, Eikenella sp. HOT 009 | 1.03 |
| Capnocytophaga granulose, Capnocytophaga sp. HOT 326 | 1.26 | Selenomonas noxia | 1.03 |
| Haemophilus sp. HOT 035, HOT 036 | 1.25 | Selenomonas sputigena, Selemonas sp. HOT 143 | 1.03 |
| Kingella oralis | 1.18 | Aggregatibacter segnis, Aggregatibacter sp. HOT 512 | 1.03 |
| Prevotella nigrescens | 1.05 | Campylobacter concisus | 1.03 |
| Corynebacterium matruchotii | 1.05 | Streptococcus sp. HOT 070, 071 | 1.02 |
| Neisseria elongata | 1.05 | Granulicatella elegans | 1.02 |
| Fusobacterium periodontium | 1.05 | ||
| Capnocytophaga sputigena | 1.05 | ||
| Streptococcus mutans | 1.04 | ||
| Prevotella Cluster IV | 1.01 | ||
| Prevotella melaninogenica, Prevotella histicola | 1.01 | ||
Results are shown for a basic model including all infants with HOMIM microarray data (n = 63) and (in bold) a second model restricted to breast-fed infants and those born in gestational week 37 or later (n = 42). In the PLS-DA model including all 63 infants (model R2 = 0.620, Q2 = 0435), length at birth, gestational weeks, and town of residence were associated with mode of birth (VIP ≥ 1.0), whereas in the PLS-DA model restricted to breast-fed infants and infants born in or after gestational week 3 (n = 42) (model R2 = 0.693, Q2 = 0.496), only length at 3 mos was influential in addition to bacteria.
Unnamed taxa are identified by their Human Oral Taxon (HOT) number from HOMD (Dewhirst et al., 2010).
Prevotella cluster I (probe Y65) targets P. loescheii, Prevotella spp clone GU027, Prevotella spp strain C3MKM081, and Prevotella spp strain TFI B31FD (HOT numbers 317, 472, 658).
Lactobacillus cluster I (probe W94) targets L. casei, L. paracasei, and L. rhamnosus.