Table 3.
Univariate analysis of brain metastases side
| Metastasis side | P χ2 test | |||
|---|---|---|---|---|
| Right (N) | Left (N) | Bilateral (N) | ||
| Patient-related variables | ||||
| Sex | ||||
| Male/female | 11/1 | 9/0 | 15/3 | 0.546 |
| Age | ||||
| Mean ± SD | 57.7 ± 8.3 | 62.6 ± 9.9 | 61.9 ± 8.7 | 0.349a |
| Pack-years | ||||
| Mean ± SD | 80.8 ± 20.2 | 84.0 ± 19.6 | 68.6 ± 26.8 | 0.202a |
| COPD | ||||
| No/yes | 6/6 | 5/4 | 10/8 | 1.000 |
| Arterial hypertension | ||||
| No/yes | 10/2 | 4/5 | 7/11 | 0.050 |
| Coronary disease | ||||
| No/yes | 12/0 | 9/0 | 13/5 | 0.054 |
| Diabetes mellitus | ||||
| No/yes | 11/1 | 9/0 | 14/4 | 0.406 |
| Gastritis/ulcer | ||||
| No/yes | 12/0 | 7/2 | 17/1 | 0.216 |
| Hypothyroidism | ||||
| No/yes | 12/0 | 6/3 | 15/3 | 0.063 |
| Other comorbidity | ||||
| No/yes | 11/1 | 7/2 | 15/3 | 0.740 |
| Disease-related variables | ||||
| Histotype | ||||
| Non-differentiated NSCLC | 6 | 2 | 7 | 0.194 |
| Squamous | 2 | 4 | 5 | |
| Adenocarcinoma | 3 | 3 | 6 | |
| Large cell carcinoma | 1 | 0 | 0 | |
| Location | ||||
| Central/peripheral | 10/2 | 8/1 | 15/3 | 1.000 |
| Diagnosis to brain metastases time (weeks) | ||||
| Median (IR) | 18 (4–40) | 0 (0–26) | 14 (0–36) | 0.632b |
a
Notes: Analysis of variance;
b
Kruskall–Wallis test.
Abbreviations: COPD, chronic obstructive pulmonary disease; IR, interquartile range; NSCLC, non-small cell lung cancer; SD, standard deviation.