Table 4.
Univariate analysis of brain metastases lobes
| Metastasis lobe | P Fisher’s exact test | ||
|---|---|---|---|
| 1 lobe (N) | ≥2 lobes (N) | ||
| Patient-related variables | |||
| Sex | |||
| Male/female | 19/2 | 16/2 | 1.000 |
| Age | |||
| Mean ± SD | 61.0 ± 9.5 | 60.6 ± 8.3 | 0.891a |
| Pack-years | |||
| Mean ± SD | 79.1 ± 19.8 | 72.2 ± 28.0 | 0.377a |
| COPD | |||
| No/yes | 12/9 | 9/9 | 0.656b |
| Arterial hypertension | |||
| No/yes | 13/8 | 8/10 | 0.276b |
| Diabetes mellitus | |||
| No/yes | 21/0 | 13/5 | 0.015 |
| Coronary disease | |||
| No/yes | 20/1 | 14/4 | 0.104 |
| Hypothyroidism | |||
| No/yes | 19/2 | 17/1 | 1.000 |
| Gastritis/ulcer | |||
| No/yes | 18/3 | 15/3 | 1.000 |
| Other comorbidity | |||
| No/yes | 17/4 | 16/2 | 0.667 |
| Disease-related variables | |||
| Histotype | |||
| Non-differentiated NSCLC | 7 | 8 | 0.088 |
| Squamous | 5 | 6 | |
| Adenocarcinoma | 8 | 4 | |
| Large cell carcinoma | 1 | 0 | |
| Location | |||
| Central/peripheral | 17/4 | 16/2 | 0.667 |
| Diagnosis to brain metastases time (weeks) | |||
| Median (IR) | 17 (0–32) | 8 (0–36) | 0.922c |
a
Notes: Student’s t-test;
b
Pearson’s χ2 test;
c
Mann–Whitney test.
Abbreviations: COPD, chronic obstructive pulmonary disease; IR, interquartile range; NSCLC, non-small cell lung cancer; SD, standard deviation.