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HRs (solid line) on a continuous basis derived from a cubic spline regression model with 4 knots (vertical dotted lines) placed at the 5th, 35th, 65th, and 95th percentiles of dietary folate intake (μg/d). The dashed lines represent the 95% CIs for the spline curve. The model was adjusted for age, sex, smoking, physical activity, use of aspirin/nonsteroidal antiinflammatory drugs, BMI, dietary calcium, and red meat intake. CRC, colorectal cancer.
