Table 2.

Serum Total and Free Testosterone, Luteinizing Hormone and Follicle-Stimulating Hormone, and Sex Hormone–Binding Globulin Levels^*

	No Exercise		Exercise
	Placebo	Testosterone	Placebo	Testosterone
Testosterone, nmol/L†‡
Baseline	6.1 (0.7)	7.1 (0.8)	7.0 (1.0)	7.0 (1.2)
Week 16	5.0 (0.5)	11.7 (1.6)	7.4 (1.2)	10.8 (1.9)
Change from baseline	−1.2 (0.6)	4.5 (1.8)§	0.4 (1.0)	3.8 (2.1)§
P value	.06	.03	.62	.05
Free testosterone, pmol/L†‡
Baseline	100.5 (13.9)	111.0 (13.9)	117.9 (17.3)	93.6 (13.9)
Week 16	107.5 (20.8)	183.8 (24.2)	121.4 (13.9)	166.4 (20.8)
Change from baseline	1.0 (24.2)	72.8 (27.7)	3.5 (13.9)	69.3 (20.8)
P value	.70	.02	.57	.02
Luteinizing hormone, U/L||
Baseline	5.0 (1.0)	3.4 (0.4)	4.3 (0.9)	6.6 (2.0)
Week 16	3.7 (0.8)	0.3 (0.1)	4.6 (1.0)	0.6 (0.3)
Change from baseline	−1.4 (0.7)	−3.1 (0.4)§	0.3 (0.2)	−6.0 (1.8)§
P value	.17	,.001	.39	,.001
Follicle-stimulating hormone, U/L||
Baseline	5.8 (1.8)	4.5 (0.5)	7.1 (1.9)	8.6 (2.6)
Week 16	5.0 (2.0)	0.5 (0.2)	6.7 (1.6)	2.0 (1.2)
Change from baseline	−0.8 (0.8)	−4.2 (0.4)¶	−0.4 (0.7)	−6.5 (1.6)¶
P value	.20	,.001	.71	,.001
Sex hormone–binding globulin, nmol/L
Baseline	66.4 (12.1)	48.6 (8.8)	52.0 (12.9)	47.5 (8.3)
Week 16	63.7 (16.8)	41.7 (7.0)	49.1 (9.5)	41.7 (8.9)
Change from baseline	−2.7 (8.3)	−6.9 (3.1)	−2.9 (3.8)	−5.8 (2.4)
P value	.75	.05	.46	.05

^*The data represent the mean (SEM) of all available values on that day. However, the change represents the difference between paired values only.

^†Overall analysis of variance is P<.03.

^‡To convert total testosterone levels to nanograms per deciliter, multiply by 28.843. To convert free testosterone levels to picograms per milliliter, multiply by 0.28843.

^§P<.05 vs placebo, no exercise.

^||Overall analysis of variance, P<.001.

^¶P<.05 vs placebo, no exercise, and placebo with exercise.