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Viability of BT-474 cells overexpressing HER2, with docetaxel formulations after 48 hours. Different concentrations of docetaxel ranging from 1 to 200 ng/mL either as solution (free docetaxel) or encapsulated in nanoparticles (NP-DTX) or targeted (NP-DTX-HER or NP-DTX-RIT) were tested. Unloaded nanoparticles was used as controls.
Abbreviations: DTX, docetaxel; HER, herceptin; RIT, irrelevant mAb; HER2, human epidermal growth factor receptor 2; NP, nanoparticle.
