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Schematic representation showing the mechanism for the IL-6-mediated increase in the TJ permeability in intestinal epithelium cells. IL-6 activates the MEK/ERK and PI3K/Akt pathways through gp130/IL-6Rα interaction, which in turn enhances Cdx2 expression. The enhanced Cdx2 expression activates the claudin-2 promoter resulting in the increase in claudin-2 expression.
