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Mast cells are abundant in infertile men. Mast cells are encountered in human testicular biopsies from men with impaired spermatogenesis (for details, see Ref. 33). They are identified by immunohistochemistry and contain immunoreactive tryptase (A). These cells accumulate in the peritubular compartment (arrows in A) and show the typical features of mast cells, including electron-dense vesicles at the ultrastructural level (B).
