FIGURE 7.

Schematic model of the mechanism of brain-specific GnT-IX expression. In GnT-IX positive cells (upper), histones around the core promoter region are modified with active marks (H3K9Ac and H3K4me3), thus CTCF and NeuroD (and an additional factor) are recruited to activate GnT-IX mRNA transcription. While in GnT-IX-negative cells (lower), chromatins are repressive (marked by H3K9me2 and H3K27me3) to which the transcription factors weakly or do not bind, and GnT-IX mRNA is not transcribed.