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Aβ induces internalization of endogenous β2AR and transfected human β2AR, not β1AR in PFC neurons. A, shown is distribution of endogenous β2AR or β1AR in wild type PFC neurons and overexpressed FLAG-β2AR in β1/β2AR-KO PFC neurons after 40 min of treatment with Aβ (10−6 m) or isoproterenol (Iso, 10−7 m). B, Aβ-induced internalization of endogenous β2AR in PFC neurons was quantified by cell surface biotinylation. n = 6. *, p < 0.05 versus control by one-way ANOVA.
