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The chemical chaperone TUDCA partially rescues DN Hnf1α-induced sensitivity to ER stress. Apoptosis in DN Hnf1α cells with or without 48 h of 500 μg/ml TUDCA and 30 mm glucose, 30 h of 500 ng/ml Dox, and/or 6 h of 20 μm CPA or vehicle. *, **, and ***, p < 0.05, 0.01, and 0.001, respectively, relative to the control without Dox and without TUDCA. #, p < 0.05 relative to with Dox and without TUDCA. Data are displayed as mean ± S.E. (error bars) of four independent experiments.
