FIGURE 7.

IKKβ ablation in the brain prevents the metabolic effects of MBH-Atg7 knockdown. Nestin/IKKβ^lox/lox mice (N/IKKβ^l/l) and littermate controls (IKKβ^lox/lox mice, IKKβ^l/l) were maintained under chow feeding since weaning. At an adult age, mice were bilaterally injected with lentivirus to deliver Atg7 shRNA or control shRNA to the MBH. Following injection, mice were maintained on either chow feeding (A and B) or HFD feeding (C and D). The longitudinal body weight (A and C) and daily food intake (B and D) of these mice were followed up. *, p < 0.05; n = 6–8 per group. Data are presented as mean ± S.E.