FIGURE 6.
Comparison of the hydrophobic and charged residues at the dimer interface of OmpR/PhoB subfamily members. A, shown is sequence alignment of the residues comprising the dimer interface of ChxR, HP1043 (atypical), and PhoB (typical). The secondary structures of ChxRRec and PhoB are indicated above and below the alignment, respectively. Blue and orange highlights represent residues involved in hydrophobic and ionic interactions, respectively. B, hydrophobic interaction between ChxRRec monomers occurs through Phe-75, Val-81, Leu-84, Trp-89, Ile-99, and Leu-106 in each monomer, whereas ionic interactions occur through Glu-78 and Arg-98 and potentially through Asp-85 and Lys-101 between each monomer. C, shown is the electrostatic potential surface of the dimer interface of ChxR, HP1043, and PhoB.