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. 2011 Jul 11;286(37):32513–32524. doi: 10.1074/jbc.M111.225862

FIGURE 1.

FIGURE 1.

Inflammatory versus apoptotic caspase activation in THP-1 cell-free extracts. A, spontaneous processing of inflammatory caspases and IL-1β in THP-1 cell-free extracts incubated at 37 °C. B, caspase-1 and IL-1β processing in THP-1 cell-free extracts in the presence or absence of the caspase inhibitor YVAD-CHO (5 μm). C, processing of endogenous caspases in THP-1 cell-free extracts under control (10 μm YVAD-CHO), inflammasome (37 °C incubation) or apoptosome (50 μg/μl cytochrome c, 1 mm dATP) activating conditions. D, processing of endogenous caspase substrates in THP-1 cell-free extracts under control, inflammasome-activating, and apoptosome-activating conditions. Results are representative of at least three independent experiments.