TABLE 3.

List of GeneGo MetaCore-identified altered genes that showed direct interaction with altered miRNAs under simulated microgravity condition

Seven simulated microgravity-altered miRNAs and 400 genes were integrated into GeneGo MetaCore as mentioned in Fig. 5. Student's t test was performed with three independent experiments, and the -fold change value represents a mean value of three individual samples.

Genes	Up/down	p value	-Fold changes	Related miRNA	Others
CCNE2	Down	0.008	−2.2	miR-34a
HMGA2	Down	0.004	−2.2	miR-34a
EGR2 (Krox20)	Up	0.01	2.1	miR-150
ZNF-145	Down	0.027	−2.3	miR-222
UBQTN C	Down	0.025	−2.3		Key in direct interaction
ETS1	Up	0.023	2.2		Key in direct interaction
c-REL	Up	0.038	2.1		Key in direct interaction