FIGURE 1.

Adiponectin improves DOX-induced cardiac dysfunction. A, Kaplan-Meier survival analysis of WT and KO mice following DOX or vehicle administration (n = 11 in each group). B, representative M-mode echocardiograms for WT or KO mice at 5 days after DOX or vehicle injection. Vertical scale bar, 1 mm; horizontal scale bar, 200 ms. C–E, quantitative analysis of the LVDd (C), LVDs (D), and %FS (E) for WT and KO mice at 5 days after DOX injection (n = 5). F, quantitative analysis of %FS in WT and APN-KO mice treated with Ad-β-gal or Ad-APN at 5 days after DOX injection. Ad-APN or Ad-β-gal (2 × 10⁸ pfu total) was delivered intravenously via the tail vein 3 days before DOX injection (n = 5). Results are presented as mean ± S.D.