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. 2011 Jun 6;208(6):1243–1252. doi: 10.1084/jem.20102477

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© 2011 Schwickert et al.

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Figure 2. — Competition inhibits early proliferation and activation of low-affinity B cells. (A) Diagrammatic representation of the experimental protocol. (B) Flow cytometric analysis of transferred B1-8^lo CD45.1⁺ CFSE-labeled B cells in draining lymph nodes 4 d after immunization. Gated on CD19⁺Igλ⁺CD45.1⁺ cells. (top) Representative CFSE dilution histograms. (bottom) Representative FAS/GL-7 dot plots. (C) Quantification of B. (left) Percentage of divided (CFSE^low) B1-8^lo B cells. (right) Percentage of FAS^intGL-7⁺ B1-8^lo cells. Each symbol represents one mouse. Error bars are SEM. Data are from three independent experiments with one to three mice per condition per experiment. **, P < 0.01; ***, P < 0.001 compared with B1-8^lo in MD4 host.

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