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. 2011 Jun 6;208(6):1243–1252. doi: 10.1084/jem.20102477

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© 2011 Schwickert et al.

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Figure 6. — Increased T cell help drives greater GC occupancy and plasmablast differentiation. (A) Diagrammatic representation of the experimental protocol. (B) Flow cytometric analysis of transferred B1-8^hiDEC205^+/+CFP⁺ and B1-8^hiDEC205^−/−CD45.1⁺ B cells in draining lymph nodes 6 d after immunization. (top) GC occupancy. Gated on CD19⁺Igλ⁺GL-7⁺FAS⁺. (bottom) Composition of plasmablast compartment. Gated on CD138^hiB220^int. (C) Quantification of data in B. Each symbol represents one mouse. Data are from three independent experiments with one to two mice per condition per experiment. CS, P. falciparum circumsporozoite protein (used as a control antigen).

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