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. 2011 Jun 6;208(6):1243–1252. doi: 10.1084/jem.20102477

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© 2011 Schwickert et al.

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Figure 7. — B cells with higher surface MHC preferentially interact with cognate T cells at the T–B border. (A) Diagrammatic representation of the experimental protocol. (B) Collapsed z stacks of three-dimensional image series of T–B border clusters in living mice. Arrowheads indicate long-lasting conjugates (>10 min) between OT-II T cells (red) and either B1-8^hiDEC205^+/+ (green) or B1-8^hiDEC205^−/− (cyan) B cells. (C) Quantification of T–B cell interactions in intravital videos. Pie charts represent the proportion of long-lasting T–B conjugates involving DEC205^+/+ and DEC205^−/− B1-8^hi B cells. The total number of conjugates analyzed is indicated in the center of each chart. The charts represent pooled data from multiple videos taken from three independent experiments, one mouse per condition per experiment. CS, P. falciparum circumsporozoite protein (used as a control antigen).

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