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. 2011 Jun 6;208(6):1229–1242. doi: 10.1084/jem.20101880

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© 2011 Correa et al.

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Figure 3. — tPA expression in the white matter is altered with age. (a–c) Photomicrographs from 4- and 9-mo-old C57/bl6 mice tissue sections show representative images of tPA (a, b, and c, red), APC (a, green; c, blue), and collagen IV (b and c, green) immunoreactivities in the corpus callosum of young (4 mo) and old (9 mo) mice. Filled arrowheads show colocalization of tPA and APC immunoreactivities. Empty arrowheads show tPA immunostaining not associated with vessels. Asterisks show colocalization of tPA and collagen IV immunostainings. (representative images, n = 3). (d and e) Quantification of OLs expressing tPA (APC⁺/tPA⁺; d) and total number of OLs (APC⁺; e) in the corpus callosum of young (4 mo) and old (9 mo) mice (mean + SEM; n = 3). ^#, significantly (P < 0.05) different from 4-mo-old mice, Mann-Whitney U test.