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. 2011 Sep 14;6(9):e24190. doi: 10.1371/journal.pone.0024190

Figure 4. Symmetry breaking.

Figure 4

(A) Hippocampal neurons were fixed shortly after plating and immunolabeled with a neuron-specific anti-Inline graphic tubulin antibody (red), an anti Sec8 antibody (green) and a nuclear marker (blue). The right panel shows a pseudocolor image of the Sec8 only. Scale bar 5 Inline graphic. (B) Experimental results, Sec8, (open circles) compared with numerical simulations, Inline graphic, (red line) for the round neuron shown in the inset. Initial profile (random perturbations) in black. In this case Inline graphic, Inline graphic, Inline graphic, Inline graphic, Inline graphic, Inline graphic and Inline graphic. (C) Temporal evolution of the simulation shown in (B) (Inline graphic axis, membrane position; Inline graphic axis, time; color scale, normalized Inline graphic values). Results are normalized to the final maximum value of Inline graphic.