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. 2011 Sep 14;6(9):e24768. doi: 10.1371/journal.pone.0024768

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Ma et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) IL-17 locus is opened up upon differentiation to Th17 cells. H3-Acetyl and H3-K4M, both chromatin modifications indicating active gene locus, were measured in WT naïve T cells or differentiated Th17 cells; (B-C) IL-17 locus is in open sate in TCF-1^-/- cells. H3-Acetyl and H3-K4M were compared between WT or TCF-1^-/- thymocytes (B) or peripheral T cells. DNA was precipitated with anti-acetyl-histone H3 (H3-Acetyl) or trimethyl-histone H3 (H3-K4M3) antibodies. qRT- PCR-based ChIP analysis was used to measure acetyl-histone H3 or trimethyl-histone within the IL-17 locus; n = 4 for each group; error bars indicate ±SEM.